This is called the. There are two forms. Silent alpha thalassemia carriers have no signs or symptoms of the disease, but are able to pass thalassemia on to their children. Blood tests are usually normal. Alpha thalassemia can cause low red blood cell levels (mild anemia) and should not be confused with not having enough iron in the blood. A DNA test is needed to make a diagnosis of alpha thalassemia. The patient should be screened first by requesting a CBC and Hemoglobin Electrophoresis. Children with alpha thalassemia trait and those who are silent carriers have no symptoms at all.Some of the more common symptoms of alpha thalassemia include: 1. fatigue, weakness, or shortness of breath 2. a pale appearance or a yellow color to the skin (jaundice) 3. irritability 4. deformities of the facial bones 5. slow growth 6. a swollen abdomen 7. dark urine You may also have an enlarged liver or spleen, yellowish skin, and leg ulcers. In alpha-thalassaemia trait, the Hb does not usually decline below 90 g/L (9 g/dL) and therefore intervention is not typically required. This is confirmed by DNA tests. This is caused due to the absence or the inactivity of one or two copies of the alpha globin gene. At Another Johns Hopkins Member Hospital: Atypical Hemolytic Uremic Syndrome (aHUS). People with alpha thalassemia may have no symptoms. Background: α-Thalassemia is a benign condition that is often present in patients with diabetes mellitus. The signs and symptoms of alpha thalassemia vary depending on the type that a child has and how severe it is. Saving children. You have a greater risk of having a child with alpha thalassemia major. The two genes can either occur on the same chromosome (cis-type) or on each of the pair (trans-type). Testing of the alpha globin genes is the only way to determine silent alpha thalassemia trait. Alpha thalassemia trait: Thalassemia is an inherited blood disorder characterized by abnormal synthesis of hemoglobin. • Adult hemoglobin (hemoglobin A) is made of alpha and beta globins. The alpha thalassemia (α-thalassemia) syndromes are a group of hereditary anemias of varying clinical severity. Alpha thalassemia trait: Introduction. This is a genetic disease inherited from one or both parents. In alpha-thalassemia, the severity of thalassemia you have depends on the number of gene mutations you inherit from your parents. If you don’t have symptoms, you may still want to see a specialist. Alpha-Thalassemia, also referred to as α-Thalassemia is a type of Thalassemia that is caused by a deficiency of the alpha globin protein. Most children with moderate to severe thalassemia show signs and symptoms within their first two years of life. Daily doses of folic acid, a vitamin vital to hemoglobin production. Outside the newborn period, it is not possible to make this diagnosis by conventional methods. Both types of alpha thalassemia trait are common in people of Southeast Asian, Southern Chinese, Mediterranean and Middle Eastern descent; however, the cis type of trait is more common. In a pregnant woman, the baby is diagnosed using CVS (chorionic villus sampling) or amniocentesis. Beta thalassaemia major is the most severe type. Here, we evaluated the effects of different genotypes α-thalassemia on HbA 1c measurement.. Methods: A total of 189 samples from nondiabetic patients were analyzed. protein chain. The only risk factor is having a family history of the disease. It develops when beta globin genes are missing. In order to make alpha globin, you need to have four genes, two from each parent. 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